Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that is primarily used to treat pain, inflammation, and swelling. It is commonly prescribed by doctors for conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. While diclofenac is considered to be a highly effective medication when used appropriately, it is important to note that there are certain substances that should not be mixed with it.
One of the most important things to avoid when taking diclofenac is other NSAIDs. This includes medications such as aspirin, ibuprofen, and naproxen. Mixing different NSAIDs can increase the risk of adverse effects, such as stomach ulcers, bleeding, and liver damage. Patients who are taking diclofenac should be careful to avoid taking other NSAIDs unless specifically advised to do so by their doctor.
Another substance that should be avoided when taking diclofenac is alcohol. Alcohol can increase the risk of side effects associated with the medication, such as stomach bleeding and liver damage. Patients who are taking diclofenac should avoid drinking alcohol while they are on the medication. If they do choose to drink, it should be in moderation and they should discuss this with their doctor to ensure it is safe.
Patients who are taking blood thinners, also known as anticoagulants, should also be careful when taking diclofenac. This is because the medication can increase the risk of bleeding, which can be a serious concern for patients who are already taking a blood-thinning medication. Patients who are taking anticoagulants should be monitored carefully while taking diclofenac and should discuss any concerns with their doctor.
It is important for patients to inform their doctor about all medications and supplements they are taking to ensure that there are no interactions with diclofenac. This includes prescription medications, over-the-counter medications, and herbal supplements. Patients should never start or stop taking any medication without first consulting their doctor.
Diclofenac is a highly effective medication for treating pain, inflammation, and swelling. However, patients should be aware of certain substances that should not be mixed with the medication, including other NSAIDs, alcohol, and blood thinners. Patients should discuss any concerns they have with their doctor and inform them of all medications and supplements they are taking to ensure that diclofenac is used safely and effectively.
Does diclofenac interact with anything?
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain, fever, and inflammation. As with any medication, diclofenac can interact with other drugs and substances, both positively and negatively. Therefore, it is important to discuss any medication or supplement use with a healthcare professional prior to taking diclofenac.
Firstly, diclofenac can interact with other NSAIDs, increasing the risk of gastrointestinal bleeding or ulceration. Similarly, taking diclofenac with other anticoagulants such as aspirin or warfarin can increase the risk of bleeding as well. Furthermore, certain medications such as corticosteroids, selective serotonin reuptake inhibitors (SSRIs), and lithium can increase the risk of gastrointestinal bleeding when taken with diclofenac.
In addition, diclofenac can interact with some drugs used to treat hypertension, such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), decreasing their effectiveness. Similarly, diclofenac can also interact with diuretics, leading to a decrease in their efficacy.
Diclofenac can also interact with certain antibiotics such as ciprofloxacin and levofloxacin, increasing the risk of seizures. This interaction is related to the inhibition of an enzyme called CYP1A2, which is responsible for breaking down these antibiotics. Therefore, taking diclofenac with these antibiotics may result in increased levels of the drugs in the body, leading to toxicity.
Furthermore, diclofenac can interact with alcohol, increasing the risk of gastrointestinal bleeding or ulceration. Therefore, it is recommended to avoid drinking alcohol while taking diclofenac.
Diclofenac can interact with a variety of drugs and substances, and it is important to discuss any medication or supplement use with a healthcare professional prior to taking diclofenac. Some potential interactions include increased risk of bleeding or ulceration, decreased efficacy of certain drugs, and risk of seizures.
Therefore, close monitoring and modification of medication regimens may be necessary to prevent adverse effects.
Why are doctors reluctant to prescribe diclofenac?
Doctors are reluctant to prescribe diclofenac for a number of reasons. Firstly, diclofenac belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs) which are known to cause gastrointestinal (GI) problems such as bleeding, ulcers and perforations. Diclofenac has been specifically associated with a higher risk of GI complications compared to other NSAIDs.
Since NSAIDs are common painkillers used for a variety of conditions, doctors may weigh the potential risks of diclofenac against the benefits of the drug and decide against prescribing it in favor of a safer alternative.
Another reason for the reluctance to prescribe diclofenac is the risk of cardiovascular events such as heart attack and stroke. Research has shown that NSWIDs, including diclofenac, can increase the risk of cardiovascular events, particularly in patients with pre-existing cardiovascular disease. Due to these potential risks, doctors are often hesitant to prescribe diclofenac, especially to patients with a history of heart disease or other cardiovascular risk factors.
In addition to the above reasons, there is also a growing concern about the environmental impact of diclofenac. Diclofenac has been found to be toxic to birds and other wildlife, and there have been reports of widespread vulture deaths due to the ingestion of diclofenac-contaminated carcasses in India.
As a result, several countries including India, Pakistan, Bangladesh and Nepal have banned or restricted the use of diclofenac in veterinary medicine. This concern with the environmental impact of diclofenac may cause doctors to avoid prescribing the drug in the long-term by considering alternative pain management strategies.
The concerns surrounding the side effects of diclofenac, including GI complications, cardiovascular events and environmental damage, have made doctors hesitant to prescribe the drug. However, in some cases, diclofenac may still be considered the best option for treating certain medical conditions, and doctors must carefully weigh the potential risks and benefits of prescribing it on a case-by-case basis.
Is diclofenac the strongest anti-inflammatory?
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain and inflammation in conditions such as arthritis, menstrual cramps, and other acute and chronic pain conditions. It is a potent inhibitor of cyclooxygenase (COX) enzymes, which are responsible for the synthesis of prostaglandins that contribute to inflammation, pain, and fever.
While diclofenac is a powerful and effective anti-inflammatory agent, it may not be the strongest one available. There are various other NSAIDs and other classes of drugs that may have comparable or even greater anti-inflammatory potency depending on the specific condition being treated, the individual patient’s response, and other factors.
For example, other NSAIDs such as ibuprofen, naproxen, and aspirin are commonly used for pain and inflammation and may be equally effective or more effective than diclofenac in certain cases. Topical NSAIDs such as diclofenac gel or patches may also be preferred over oral medications for localized pain and inflammation.
Corticosteroids are another class of anti-inflammatory drugs that can be much more potent than NSAIDs and are often used in more severe and chronic inflammatory conditions such as asthma, rheumatoid arthritis, and lupus. However, corticosteroids have significant side effects and are not suitable for long-term use in most cases.
Biologic drugs such as tumor necrosis factor (TNF) inhibitors and interleukin (IL) inhibitors are even more powerful and targeted anti-inflammatory agents that are used to treat autoimmune diseases and other inflammatory conditions. These drugs can be very expensive and have potential risks and side effects, but may be necessary for patients with more severe or refractory disease.
While diclofenac is a widely used and effective anti-inflammatory drug, it may not be the strongest or most appropriate option for all patients and conditions. It is important to consult with a healthcare provider to determine the best treatment plan for individual needs and to balance the benefits and risks of different anti-inflammatory agents.
What are the worst side effects of diclofenac?
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation caused by conditions such as arthritis, gout, and menstrual cramps. Like all medications, diclofenac carries a risk of potential side effects, ranging from mild to severe. Some of the worst side effects of diclofenac are as follows:
1. Gastrointestinal problems: NSAIDs like diclofenac can cause a range of gastrointestinal issues, including stomach ulcers, bleeding, and perforation. These side effects can be life-threatening and often require hospitalization.
2. Cardiovascular problems: While diclofenac is not typically associated with an increased risk of heart attack or stroke, studies have shown that long-term use of high doses can increase cardiovascular risks. Patients with pre-existing heart or vascular conditions are more susceptible to these risks.
3. Kidney damage: NSAIDs like diclofenac can put a strain on the kidneys, causing damage over time. This can lead to kidney failure, which requires dialysis or a kidney transplant.
4. Liver damage: Rare cases of liver damage have been reported in patients taking diclofenac, with symptoms such as yellowing of the skin or eyes, dark urine, and abdominal pain. In severe cases, liver failure can occur, which is life-threatening.
5. Allergic reactions: Some patients may develop an allergic reaction to diclofenac, which can range from mild symptoms like a rash or hives to severe reactions like anaphylaxis, a potentially life-threatening condition that affects breathing and blood pressure.
It’s important to note that not all patients will experience these side effects, and many patients tolerate diclofenac well. However, patients with underlying health conditions, such as kidney or liver disease, should use caution when taking diclofenac and discuss the risks and benefits with their doctor.
It’s also important to follow the prescribed dose and talk to a healthcare professional if any side effects develop.
What drug interacts with diclofenac topical?
Diclofenac topical is a non-steroidal anti-inflammatory drug (NSAID) used to relieve localized pain and inflammation in the body. It is commonly used as a topical gel or cream, and it works by inhibiting the production of the hormone-like substances known as prostaglandins, which play a role in inflammation and pain.
While diclofenac topical is generally safe and effective, it can interact with other drugs, which can lead to unwanted side effects or reduced effectiveness.
One drug that can interact with diclofenac topical is warfarin, which is an anticoagulant medication used to prevent blood clots. Diclofenac can interfere with the metabolism of warfarin, which can increase the risk of bleeding. Therefore, it is important to be cautious when using these two drugs together, and patients taking both drugs should be closely monitored by their doctor.
Another drug that can interact with diclofenac topical is aspirin or other NSAID painkillers, such as ibuprofen or naproxen. Taking these drugs along with diclofenac can increase the risk of side effects, particularly gastrointestinal bleeding, stomach ulcers, or perforation of the digestive tract.
It is important to avoid taking these medications concurrently, or to use them only under the guidance of a healthcare provider.
Other drugs that can interact with diclofenac topical include corticosteroids, which are often used to treat inflammation in the body; methotrexate, a drug used to treat cancer and autoimmune diseases; and cyclosporine, a drug used to prevent organ rejection after transplant surgery. In addition, diclofenac may interact with certain blood pressure medications, including ACE inhibitors and diuretics, as well as lithium, a medication used to treat bipolar disorder.
As with any medication, it is important to disclose all medications and supplements being taken with the prescribing healthcare provider. They can properly assess and monitor potential interactions, evaluating any risks or benefits. If any concerning symptoms arise, it is important to contact the healthcare provider immediately.
Can I take diclofenac and Tylenol together?
Diclofenac and Tylenol are two different types of medications used to relieve pain and reduce fever. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by blocking certain chemicals in the body that cause inflammation and pain. Tylenol, on the other hand, contains acetaminophen which works by reducing fever and blocking pain signals in the brain.
While it is possible to take diclofenac and Tylenol together, it is important to know that these two medications work differently and may have different effects on the body. It is always best to consult with a healthcare provider before combining medications to ensure that it is safe and appropriate for your individual needs.
Additionally, taking both diclofenac and Tylenol may increase the risk of side effects such as stomach upset and ulcers. Both medications can also have an impact on the liver and kidneys, so it is important to avoid taking more than the recommended dose and to monitor any changes in your health closely.
In general, it may be safer to alternate between the two medications rather than taking them at the same time. For example, you could take diclofenac in the morning, and Tylenol later in the day if needed. Alternatively, you could consider other pain relief options such as topical creams or physical therapy to reduce the need for medication altogether.
While it is possible to take diclofenac and Tylenol together, it is important to do so under the guidance of a healthcare provider. They can provide personalized advice and help you manage any potential risks or side effects associated with combining these medications.
What is the controversy with diclofenac?
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) which is widely used for treating pain, inflammation and fever. However, it has been surrounded by controversies for many years. One of the biggest controversies related with diclofenac is its side effects on the liver and the cardiovascular system.
Many studies have shown that the long-term use of diclofenac can increase the risk of liver damage and liver failure. The drug can cause abnormal liver function tests and increase liver enzymes levels. In severe cases, it can cause acute liver failure, which can be fatal. This is especially concerning for people who already have liver problems, such as hepatitis or cirrhosis.
Another controversy surrounding diclofenac is its potential harmful effects on the cardiovascular system. Several studies have shown that diclofenac can increase the risk of heart attack and stroke, especially in people with a history of heart disease or stroke. This is because diclofenac can increase blood pressure, cause blood clots, and reduce blood flow to the heart and brain.
Apart from the liver and the cardiovascular system, diclofenac is also known to cause gastrointestinal problems, such as stomach ulcers and bleeding. This is why the drug is often prescribed with a protective agent, such as a proton pump inhibitor, to reduce the risk of gastrointestinal side effects.
Despite these controversies, diclofenac is still widely used around the world as a pain reliever and anti-inflammatory drug. It is available in many forms, including oral tablets, topical gels and creams, and injections. However, it is important to use diclofenac only as prescribed by a healthcare provider, and to be aware of the potential risks and side effects associated with the drug.
The controversy surrounding diclofenac stems from its potential harmful effects on the liver, the cardiovascular system, and the gastrointestinal tract. While the drug continues to be a useful tool in the management of pain and inflammation, it should be used with caution and only under the guidance of a healthcare professional.
Can you take diclofenac with blood pressure medication?
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to treat various painful conditions, such as arthritis, menstrual cramps, and acute pain. High blood pressure or hypertension is a chronic medical condition that affects millions of people worldwide. There are different classes of antihypertensive medications available, and they work by different mechanisms to lower blood pressure levels in the body.
When it comes to the question of whether diclofenac can be taken with blood pressure medication, the answer depends on the type of blood pressure medication that is being taken. Some blood pressure medicines are compatible with diclofenac, while others can interact with this NSAID, causing adverse effects.
For instance, if an individual is taking angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) for hypertension, taking diclofenac can reduce the antihypertensive effects of these medications. Diclofenac may also increase the risk of kidney damage in people taking these antihypertensive drugs, particularly in individuals with pre-existing kidney problems.
On the other hand, medications such as calcium channel blockers or diuretics may not interact significantly with diclofenac. However, it is always recommended to consult a doctor or pharmacist before taking diclofenac along with any blood pressure medication to avoid any potential harmful interactions.
It is also essential to note that taking diclofenac for an extended period can lead to an increased risk of cardiovascular events such as heart attack and stroke, particularly in people with pre-existing heart or blood vessel diseases. As such, individuals with hypertension and other underlying cardiovascular conditions should exercise caution when using diclofenac and should only take this medication under the guidance of a healthcare professional.
While diclofenac may be useful in managing pain or inflammation, it may interact with some blood pressure medications. Thus, it is always recommended to consult a healthcare provider before using diclofenac or combining it with other medications. Additionally, people with hypertension or other cardiovascular conditions should be cautious when using diclofenac and should use this medication only under the supervision of a medical professional.
Is diclofenac hard on your heart?
Diclofenac is a commonly used nonsteroidal anti-inflammatory drug (NSAID) that is widely used for pain relief and inflammation in various medical conditions. However, there has been a lot of concern regarding its potential cardiovascular risks, including heart attack and stroke.
Several studies have found that diclofenac use is associated with a relatively higher risk of cardiovascular complications compared to other NSAIDs, such as ibuprofen or naproxen. For instance, a large population-based study in Denmark found that diclofenac use was associated with a 50% increased risk of major adverse cardiovascular events, including heart attack, stroke, and heart failure, compared to non-use of NSAIDs.
Similarly, a meta-analysis of randomized controlled trials found that diclofenac was associated with a higher risk of major vascular events, including heart attack and stroke, compared to placebo or other NSAIDs.
One proposed mechanism for diclofenac’s cardiovascular risks is its inhibition of prostacyclin, a vasodilator and antiplatelet agent that is produced by the vascular endothelium. By inhibiting prostacyclin production, diclofenac may increase the risk of thrombosis and vasoconstriction, both of which can contribute to cardiovascular complications.
Moreover, diclofenac has been found to increase blood pressure in some patients, which can also increase the risk of cardiovascular complications, especially in patients with preexisting hypertension.
However, it is important to note that the absolute risk of cardiovascular complications with diclofenac use is still relatively low, especially in patients without preexisting cardiovascular conditions. Therefore, the decision to use diclofenac should be made on an individual basis, taking into account the patient’s overall medical condition and cardiovascular risks.
Diclofenac is associated with a relatively higher risk of cardiovascular complications compared to other NSAIDs, likely due to its inhibition of prostacyclin and potential for increasing blood pressure. However, the absolute risk of complications is still relatively low, especially in patients without preexisting cardiovascular conditions, and should be weighed against the potential benefits of diclofenac use for pain and inflammation relief.
It is always recommended to talk to a healthcare professional before taking diclofenac or any other medication.
Is diclofenac OK with high blood pressure?
Diclofenac is a non-steroidal anti-inflammatory drug that is commonly used to treat pain and inflammation caused by various conditions such as arthritis, migraine, and menstrual cramps. However, diclofenac can also cause side effects that can be harmful to people who have certain health conditions, such as high blood pressure.
Diclofenac works by reducing the production of prostaglandins, which are chemicals that cause pain and inflammation. However, prostaglandins also play a role in regulating the blood vessels in the body, including those in the kidneys. When diclofenac reduces the production of prostaglandins, it can cause the blood vessels to constrict and increase blood pressure, which can be dangerous for people who have high blood pressure.
Therefore, it is important to consult with a healthcare provider before taking diclofenac if you have high blood pressure. Your healthcare provider will evaluate your blood pressure level and determine if diclofenac is safe for you to take. If you have high blood pressure, your healthcare provider may recommend alternative pain relief options that are safer for you.
Additionally, if you are already taking medication for high blood pressure, it is important to inform your healthcare provider before taking diclofenac. Some medications for high blood pressure can interact with diclofenac and cause adverse side effects.
Diclofenac can be dangerous for people with high blood pressure. It is important to consult with a healthcare provider before taking diclofenac and inform them if you have high blood pressure or are taking medication for high blood pressure. Your healthcare provider may recommend alternative pain relief options that are safer for you.
How long does diclofenac take to reduce inflammation?
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain and inflammation. The length of time it takes for diclofenac to reduce inflammation varies depending on several factors, including the severity of the inflammation, the dosage of diclofenac, and how the medication is administered.
Diclofenac is available in oral tablets, capsules, and liquid form, as well as topical gels, creams, and patches. The time it takes for diclofenac to reduce inflammation will depend on how the medication is administered. For example, the topical forms of diclofenac may work more quickly for localized inflammation in the skin or joints, while oral forms may take longer to take effect on inflammation in deeper tissues and organs.
In general, diclofenac begins to reduce inflammation within 30 minutes to an hour of taking the medication orally. However, it may take several hours for the medication to reach its full effect in reducing inflammation. Topical forms of diclofenac may work more quickly, with some formulations targeting pain relief within 15 minutes of application.
The dose and frequency of taking diclofenac will also affect the length of time it takes to reduce inflammation. Higher doses of diclofenac may provide more rapid and effective relief of inflammation, but they may also increase the risk of side effects. It is important to follow the instructions of a healthcare provider when taking diclofenac to ensure safe and effective use.
Additionally, the severity of the inflammation will affect the length of time it takes for diclofenac to work. Mild inflammation may respond more rapidly to diclofenac than severe inflammation. If the inflammation is due to an underlying medical condition, it may take longer for the medication to reduce inflammation, and other treatments may be necessary.
The length of time it takes for diclofenac to reduce inflammation depends on several factors, including the severity of the inflammation, the dose and frequency of diclofenac use, and the administration method of the medication. It is important to follow the instructions of a healthcare provider when taking diclofenac to ensure maximum benefit and safe use.
Is diclofenac stronger than ibuprofen 800?
Diclofenac and ibuprofen 800 are both nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used as pain relievers and fever reducers. Although they have similar mechanisms of action, they differ in potency, duration of action, and side effect profiles.
Diclofenac is regarded as a powerful NSAID with higher anti-inflammatory and analgesic properties than ibuprofen 800. It inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, which are responsible for producing prostaglandins that cause inflammation, pain, and fever. This dual inhibition leads to a faster and more effective relief of symptoms in conditions such as osteoarthritis, rheumatoid arthritis, and post-operative pain.
Additionally, diclofenac is highly lipophilic, which allows it to penetrate inflamed tissues and joints, reaching higher concentrations at the site of action.
In contrast, ibuprofen 800 is intermediate-strength NSAID that primarily inhibits COX-1 enzyme, which is important for gastric cytoprotection and platelet aggregation. While it also inhibits COX-2, it is less selective than diclofenac and may cause more gastric and renal complications. Ibuprofen 800 is commonly used for the treatment of mild-to-moderate pain caused by migraines, dental surgery, menstrual cramps, and fever.
However, the choice between diclofenac and ibuprofen 800 depends on various factors such as the severity of pain, the underlying condition, patient’s age, medical history, and drug interactions. In some cases, diclofenac may be contraindicated due to its higher risk of cardiovascular events, gastrointestinal bleeding, renal impairment, and allergy.
Similarly, ibuprofen 800 may interact with certain medications such as aspirin, anticoagulants, and angiotensin-converting enzyme inhibitors, leading to adverse effects.
Therefore, it is recommended to consult a healthcare provider before taking either diclofenac or ibuprofen 800, and to follow the prescribed doses and duration of treatment. while diclofenac is considered stronger than ibuprofen 800 in terms of potency, its use should be based on careful assessment of risks and benefits of treatment.
Which diclofenac works faster?
When it comes to medications, the speed of onset can be essential, especially in cases where pain relief is necessary. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain and reduce inflammation. It is available in different formulations, including oral tablets, suppositories, injections, and topical preparations.
The time it takes for diclofenac to take effect depends on several factors, such as the formulation, dosage, and individual’s metabolism. For example, oral tablets can take up to an hour or two to work, while topical preparations such as gels, lotions, or patches can work almost immediately, providing rapid relief to the site of pain.
In terms of oral diclofenac tablets, there are different forms of the medication, including immediate-release, delayed-release, and extended-release formulations. Immediate-release formulations are designed to kick in faster, usually within 30-60 minutes of ingestion. Delayed-release tablets are formulated to work over a more extended period, taking between 1-2 hours to start working, but providing longer-lasting pain relief.
Extended-release tablets take longer to work, typically taking hours or even days to reach peak effect, but can provide relief for up to 24 hours.
To determine which formulation of diclofenac works faster, it is essential to consider the type and source of pain. For example, for acute pain, such as a headache or menstrual cramps, immediate-release tablets might be the best option, as they can provide fast relief. However, for chronic pain, such as arthritis or back pain, a longer-acting formulation, like extended-release tablets or patches, could be more effective, as they provide sustained pain relief over a more extended period.
It is vital to consult with a healthcare professional before taking any diclofenac formulation to determine the right dosage, frequency, and formulation to use. They can assess your medical history, current medications, and other factors that can affect the effectiveness and safety of the medication.
there is no one-size-fits-all answer to which diclofenac works faster, as it depends on individual circumstances and the type of pain being treated.
Which is more effective meloxicam or diclofenac?
Meloxicam and diclofenac are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and inflammation. They are widely used in the treatment of various conditions such as arthritis, osteoarthritis, rheumatoid arthritis, and other inflammatory conditions.
In terms of effectiveness, both meloxicam and diclofenac are proven to be effective in relieving pain and inflammation. However, the choice of which drug is more effective depends on various factors such as the severity of the condition, the patient’s medical history, and individual response to the medication.
Meloxicam is usually preferred due to its long-lasting effect, which means that it can be administered once a day, making it more convenient for patients. It also has fewer gastrointestinal side effects than diclofenac, such as stomach ulcers, which makes it a safer option for patients who have a history of gastrointestinal problems.
On the other hand, diclofenac is more potent and has a faster onset of action, which may make it a better choice for patients who need immediate pain relief. It also comes in different forms such as gel, patch, and injection, which provides more options for the route of administration.
Both meloxicam and diclofenac are effective in relieving pain and inflammation. The choice of which drug to use depends on various factors, including the patient’s medical history, the severity of the condition, and the individual response to the medication. the decision should be made based on the patient’s needs and after consulting with a medical professional.